Domain knowledge will stand alone as the sole differentiator. Because LLM benefits can be reaped by almost anyone and it’s a force multiplier. Now those who have the strongest initial force will have a far bigger edge than before.
Real world domain knowledge and experience cuts through the chaff too. LLMs are going to have people reinventing the wheel and wasting tonnes of time on stuff that won't work out. If you're a domain expert you are going to be much more aware of how to focus effort in the right places, and what's actually needed or been tried before in your niche.
A lot of this domain knowledge is not in any training data, it's locked up in companies in the industry. I suspect it will get even more important to guard it.
